NEUROFUEL (formerly CILTEP) is a stimulant-free nootropic built around a single mechanism: inhibiting the enzyme PDE4 to keep cAMP elevated in brain cells, the messenger molecule involved in long-term potentiation and memory formation. It combines artichoke extract and forskolin with acetyl-L-carnitine, L-phenylalanine, and vitamin B6, and is designed to be taken consistently over days and weeks rather than as an acute boost.

Focus and motivation that builds - not spikes.

Most focus supplements work by borrowing from tomorrow. Stimulants push your nervous system harder, deliver a short window of alertness, and leave you paying it back later with a crash. NEUROFUEL works differently - it targets the cellular mechanism behind long-term memory formation and sustained mental drive, without stimulants.

Built Around a Specific Neurological Mechanism. Not Just a Stimulant Stack.

Formerly known as CILTEP (Chemically Induced Long-Term Potentiation), NEUROFUEL is built around a specific and well-reasoned mechanism: inhibiting PDE4, an enzyme that breaks down cAMP (cyclic adenosine monophosphate) in brain cells. cAMP is a critical messenger molecule involved in Long-Term Potentiation - the process by which short-term experiences become long-term memories. Keep cAMP elevated, and you strengthen the neural pathways that underpin focused thinking, learning, and recall.

The ingredients and what they do

Artichoke Extract (standardised to 5% Cynarin) contains Luteolin, a natural PDE4 inhibitor. By blocking PDE4, it keeps cAMP levels elevated in brain cells, maintaining the conditions for stronger synaptic signalling.

Forskolin (from Coleus Forskohlii) activates the enzyme adenylyl cyclase, which directly increases intracellular cAMP. Where Artichoke Extract stops cAMP from being broken down, Forskolin actively boosts its production. The two work in tandem - one prevents the drain, the other fills the tank.

Acetyl-L-Carnitine (ALCAR) is included to support the acetylcholine system alongside the cAMP mechanism. When cAMP rises, acetylcholinesterase activity also increases - which can blunt short-term memory. ALCAR helps counterbalance this, keeping both systems in check.

L-Phenylalanine is an essential amino acid used by the brain to produce dopamine and other catecholamines, supporting the motivational drive and positive mood that make focused work feel rewarding rather than effortful.

Vitamin B6 (as Pyridoxal-5-Phosphate) is included in its most bioavailable form as a cofactor for neurotransmitter synthesis - supporting the whole system rather than any single pathway.

Who it's for

NEUROFUEL is particularly well suited to knowledge workers, students, and anyone who needs to hold focus on demanding cognitive tasks for extended periods. It works best taken consistently over days and weeks rather than as an occasional boost - the mechanism involves cellular adaptation, not just acute stimulation.

It's also a core component of the Natural Stacks Mental Performance Stack, where it pairs with MagTech, Dopamine Brain Food, and Smart Caffeine.

Frequently Asked Questions

What is NEUROFUEL?
A stimulant-free nootropic, formerly sold as CILTEP, built around keeping cAMP elevated in brain cells to support memory formation and sustained focus without stimulants.

How does it work without stimulants?
It targets a cellular mechanism rather than pushing the nervous system. Artichoke extract inhibits PDE4 (which stops cAMP being broken down) while forskolin boosts cAMP production - one prevents the drain, the other fills the tank.

Is this the same as CILTEP?
Yes - same formula, renamed. NEUROFUEL is the current name for what was previously CILTEP.

How should I take it?
Three capsules per day (about a 25-day supply). Many people reduce to two per day once the effects are established, extending the bottle to around 37 days. It works best taken consistently rather than occasionally.

Who is it for?
It suits knowledge workers, students, and anyone holding focus on demanding tasks for long periods. Not suitable for children; consult your doctor if pregnant, nursing, or taking medication.

75 capsules | 25-day supply

At the recommended dose of 3 capsules per day, one bottle provides approximately 25 days of use - just under a month. Many users find they can reduce to 2 capsules per day once the effects are established, extending the supply to around 37 days.

Not suitable for children. Consult your doctor if pregnant, nursing, or taking medications.