Where to start with NAD+ and longevity
It comes back to NAD+
NAD+ is a coenzyme every cell uses for energy production and DNA repair, and levels fall as we age. Most of this category is about topping them back up, and two precursors lead the field.
Nicotinamide Riboside
NR has the clearest human evidence for raising NAD+. A placebo-controlled trial in healthy adults aged 55 to 79 found chronic NR supplementation lifted NAD+ by around 60% over the study period. Ours pairs it with astaxanthin. Shop Nicotinamide Riboside.
NMN
One step closer to NAD+ in the pathway, and the precursor with the fastest-growing human dataset behind it, including a randomised, double-blind, placebo-controlled trial in middle-aged and older adults. Shop NMN.
Spermidine
Spermidine is tied to autophagy, the cellular clean-up process where worn-out components are broken down and recycled. It is one of the most interesting mechanisms in ageing research, and ours pairs it with astaxanthin. Shop Spermidine.
Berberine and Shilajit
Berberine with Resveratrol comes at ageing from the metabolic side: berberine activates AMPK, the enzyme cells use to manage energy. Shilajit is the traditional end of the shelf, a mineral-rich resin used in Ayurvedic medicine for over 3,000 years and valued for its fulvic acid and trace minerals.
Which should you start with?
NR or NMN if NAD+ is the goal and you want the research behind you. Shilajit if you would rather start somewhere traditional. Ring us on +353 (0)1 539 0000 or email info@powerful.ie and we will talk you through it.
Frequently Asked Questions
What is NAD+ and why does it matter?
NAD+ is a coenzyme every cell uses for energy production and DNA repair. Levels decline with age, which is why a lot of this category aims to raise it, either by supplying a precursor the body converts into NAD+ or by supporting the pathways around it.
NMN or NR, which should I pick?
Both are precursors your body converts into NAD+. NR has the longer track record of published human trials showing it raises NAD+. NMN sits one step closer to NAD+ in the pathway and has a growing dataset of its own. Most people pick one and stay consistent.
Can I take them together?
Yes, and plenty of people do, though there is no need to take both precursors at once when you are starting out. A common approach is one NAD+ precursor plus something from a different pathway, such as spermidine or shilajit.
When and how should I take them?
Most are once-daily capsules taken with food and built into a routine rather than used in bursts. If you are pregnant, breastfeeding, or on medication, check with your GP or pharmacist first. Berberine in particular can interact with several common medicines.