Berberine and resveratrol are two of the most extensively studied compounds in metabolic and longevity research. Berberine activates AMPK, a cellular energy regulator linked to glucose and cholesterol metabolism; resveratrol activates sirtuins, proteins associated with cellular longevity and mitochondrial health. This formula combines 400mg berberine with 100mg organic resveratrol (from Polygonum cuspidatum) in a single daily capsule.

Two of the Most Studied Longevity Compounds, Combined

Berberine and resveratrol have each built substantial research reputations on their own. Feel Supreme combines both into a single daily formula - 400mg berberine and 100mg organic resveratrol per serving, in a clean HPMC vegetable capsule with no artificial fillers or binders.

30 servings per 60-capsule tub.

Berberine - 400mg

Berberine is a plant alkaloid found in Berberis species, and one of the most extensively studied natural compounds for metabolic health. It works primarily by activating AMPK (adenosine monophosphate-activated protein kinase) - a cellular energy regulator sometimes called the metabolic master switch.

Research published in the Journal of Clinical Endocrinology and Metabolism found berberine supports balanced glucose metabolism by enhancing insulin sensitivity (PMC2410097). A meta-analysis examining berberine's cardiovascular effects found significant reductions in LDL cholesterol and triglycerides alongside increases in HDL cholesterol (PMC5839379). Berberine also demonstrates antioxidant and anti-inflammatory activity, with research indicating it reduces markers of oxidative stress at the cellular level (PMC3746162).

Resveratrol - 100mg (Organic Polygonum Cuspidatum)

Resveratrol is a polyphenol found in red grapes and certain berries, sourced here from organic Japanese knotweed (Polygonum cuspidatum) - one of the most concentrated natural resveratrol sources available.

Its primary mechanism involves activation of sirtuins, a family of proteins linked to cellular longevity and mitochondrial function. Research in The Journals of Gerontology demonstrated resveratrol's ability to support mitochondrial resilience and cellular health with age (PMC5450289). Separately, its cardiovascular effects have been studied for its role in reducing inflammation and supporting healthy blood vessel function.

Why the Combination Works

Berberine addresses metabolic and cardiovascular markers from the cellular energy side. Resveratrol addresses cellular ageing and mitochondrial protection from the longevity side. Together they cover two of the most researched areas of preventive health in a single daily dose.

• Berberine 400mg per serving
• Organic Resveratrol 100mg per serving (Polygonum Cuspidatum)
• HPMC vegetable capsule - vegan-friendly
• No artificial fillers or binders
• 60 capsules / 30 servings

Frequently Asked Questions

What does berberine do?
It's a plant alkaloid that activates AMPK, a cellular energy regulator sometimes called the metabolic master switch. Research has linked it to balanced glucose metabolism and improvements in LDL cholesterol, triglycerides, and HDL cholesterol.

What does resveratrol do?
A polyphenol that activates sirtuins, proteins linked to cellular longevity and mitochondrial function, with research also exploring its role in inflammation and blood vessel health.

Why combine berberine and resveratrol?
They work on complementary mechanisms - berberine on metabolic and cardiovascular markers, resveratrol on cellular ageing and mitochondrial protection - covering two well-researched areas of preventive health in one capsule.

How do you take it?
Two capsules daily. The 60-capsule tub is a 30-day supply.

Who should check before taking it?
Berberine can interact with medications for blood sugar and blood pressure, so consult your doctor before use if you're on any prescription medication, pregnant, or nursing.

Take 2 capsules daily. Order before 4pm for same-day dispatch.